Lunasin Research
Lunasin is a peptide found naturally in soy that scientists have identified as the key to many of soy's documented health benefits.  More than 40 peer-reviewed and published studies have documented lunasin's health benefits.  This bioactive soy component is the subject of research by more than 25 research institutions around the world.  This research has been supported by 27 public and private funding sources and has resulted in 9 patents.  Bodies of research include: cancer prevention, cardiovascular, inflammation, skin health and anti-aging.
(Click on each study title to view abstract, researchers and publication location.)

1. Lunasin Peptide Upregulates Thrombospondin 1 (THBS1) Gene Expression in Non-Tumorigenic Prostate Epithelial Cells
 
2. Lunasin Potentiates the Effect of Oxaliplatin Preventing Outgrowth of Colon Cancer Metastasis, Binds to α5β1 Integrin and Suppresses FAK/ERK/NF-κB Signaling
 
3. Differential Expression of Thrombospondin (THBS1) in Tumorigenic and Nontumorigenic Prostate Epithelial Cells in Response to a Chromatin-Binding Soy Peptide
 
4. Lunasin-Aspirin Combination Against NIH/3T3 Cells Transformation Induced by Chemical Carcinogens

5. Relationship between lunasin’s sequence and its inhibitory activity of histones H3 and H4 acetylation
 
6. Lunasin induces apoptosis and modifies the expression of genes associated with extracellular matrix and cell adhesion in human metastatic colon cancer cells

7. Complementary Roles in Cancer Prevention: Protease Inhibitor Makes the Cancer Preventive Peptide Lunasin Bioavailable

8. Lunasin, with an arginine-glycine-aspartic acid motif, causes apoptosis to L1210 leukemia cells by activation of caspase-3

9. Lunasin promotes apoptosis in human colon cancer cells by mitochondrial pathway activation and induction of nuclear clusterin expression
 
10. Recombinant expression of bioactive peptide lunasin in Escherichia coli
 
11. The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells
 
12. Soybean Peptide Lunasin Suppresses in Vitro and In Vivo 7,12-Dimethylbenz [a]anthracene-induced Tumorigenesis

13. Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis

14. Lunasin peptide purified from Solanum nigrum L. protects DNA from oxidative damage by suppressing the generation of hydroxyl radical via blocking fenton reaction

15. Lunasin and lunasin-like peptides inhibit inflammation through suppression
of NF-kB pathway in the macrophage
 
16. Lunasin and Bowman-Birk protease inhibitor (BBI) in US commercial soy foods

17. Isolation, purification and characterisation of lunasin from defatted soybean
flour and in vitro evaluation of its anti-inflammatory activity

18. Presence of Lunasin in Plasma of Men after Soy Protein Consumption

19. Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages

20. Lunasin, a novel seed peptide for cancer prevention
 
21. Analysis of Soybean Protein- Derived Peptides and the Effect of Cultivar, Environmental Conditions, and Processing on Lunasin Concentration in Soybean and Soy Products

22. Lunasin: A Novel Cancer Preventive Seed Peptide that Modifies Chromatin

23. Bowman-Birk Inhibitor and Genistein among Soy Compounds That Synergistically Inhibit Nitric Oxide and Prostaglandin E2 Pathways in Lipopolysaccharide-Induced Macrophages

24. Bioactive Peptides in Amaranth (Amaranthus hypochondriacus) Seed

25. Role of Dietary Soy Protein in Obesity- A Review

26. In Vitro Digestibility of the Cancer-Preventive Soy Peptides Lunasin and BBI

27. Cancer-Preventive Peptide Lunasin from Solanum nigrum L. Inhibits Acetylation of Core Histones H3 and H4 and Phosphorylation of Retinoblastoma Protein (Rb)

28. Inhibition of Core Histone Acetylation by the Cancer Preventive Peptide Lunasin

29. The Potential Allergenicity of Two 2S Albumins from Soybean (Glycine max): A Protein Microarray Approach

30. Contents and Bioactivities of Lunasin, Bowman-Birk Inhibitor, and Isoflavones in Soybean Seed

31. Lunasin: A Cancer-Preventive Soy Peptide

32. Dynamics of Keratinocytes in Vivo using 2H20 Labeling: A Sensitive Marker of Epidermal Proliferation State

33. Lunasin Concentration in Different Soybean Genotypes, Commercial Soy
Protein, and Isoflavone Products

34. The Anticarcinogenic Potential of Soybean Lectin and Lunasin- Special Article

35. Lunasin Suppresses E1A-Mediated Transformation of Mammalian Cells But Does Not Inhibit Growth of Immortalized and Established Cancer Cell Lines

36. Characterization of Lunasin Isolated from Soybean

37. Barley Lunasin Suppresses ras-Induced Colony Formation and Inhibits Core Histone Acetylation in Mammalian Cells
 
38. Identification and bioavailability of a chromatin-binding peptide (Lunasin) from Korean Soybean

39. Chemopreventive Property of a Soybean Peptide (Lunasin) That Binds to Deacetylated Histones and Inhibits Acetylation

40. A soybean cDNA encoding a chromatin binding peptide inhibits mitosis of mammalian cells

41. Epigenetic Regulation of HMG-CoA Reductase and LDL Receptor Expression By The Soy Peptide Lunasin Provides Mechanism for Lowering Cholesterol