Research StudiesLunasin Research

Lunasin is a 43-amino acid polypeptide with poly (L-aspartic acid) sequence at the carboxyl terminus. It is found naturally in soy, barley, and rye. This bioactive peptide is the subject of research in more than 80 peer-reviewed and published studies by more than 30 research institutions around the world. Lunasin research has been supported by 27 public and private funding sources and has resulted in 10 patents. Bodies of research include: cancer prevention, cholesterol/cardiovascular, inflammation, skin health and anti-aging.

Loma Linda university is currently conducting a human clinical trial which is designed to validate research from prior studies. The trial is analyzing the data collected on the cholesterol lowering effects of Lunasin, as well as inflammation, oxidative stress, immune enhancements, and its effects on metabolic syndrome. 

Current research at Harvard university is an extension of the human clinical trials performed at Duke University on how Lunasin affects progression of ALS.  The Harvard study expands on Duke’s research by looking at epigenetic biomarkers (histone acetylation levels).  Gathering and analyzing this bloodwork data will show why Lunasin is effective and see where the benefits are occurring at the genetic level.  Genome wide screening of gene expression will also look at the association between Lunasin’s mechanism of action, epigenetic biomarkers, as well as the symptomatic affects in ALS patients.

 

 

Dr. Richard Bedlack, Professor and Director of the ALS Clinic at Duke University, is conducting a study on Lunasin in 50 ALS patients. The Study is a first of a kind clinical study that is investigating the efficacy Lunasin in the support of ALS. It’s the fastest enrollment study ever produced in their history. The clinical trial is based on Mike McDuff, an ALS patient who showed a remarkable reversal after taking bioactive Lunasin. He gained back his weight, went off his feeding tube and could talk again. Not all people will have the same results, but it greatly improved Mike’s quality of life.

 

List of Studies

Below is a full list of studies concerning Lunasin beginning with the most recent. To see an abstract of the article click the article’s title. Links to full articles with free access have been provided when available.

2015 Jul 1. [Epub ahead of print]
Food & Function
Author: Cruz-Huerta E, Fernández-Tomé S, Arques MC, Amigo L, Recio I, Clemente A, Hernández-Ledesma B
2015 Mar 10. 6(7):4649-62
Oncotarget
Author: Elizabeth J. McConnell, Bharat Devapatla, Kavitha Yaddanapudi, Keith R. Davis.
2015 Mar. 80(3):R485-94. Epub 2015 Jan 27
Journal of Food Science
Author: Vaibhao Kisanrao Lule, Sheenam Garg, Sarang Dilip Pophaly, Hitesh, Sudhir Kumar Tomar.
2015 Feb 3. 10(2):e0115330. eCollection 2015
PLoS One
Author: Xiaowei Yang, Jingjing Zhu, Chun-Yu Tung, Gail Gardiner, Qun Wang, Hua-Chen Chang, Baohua Zhou.
2015. 2015:346839. Epub 2015 Jan 27
Biomed Research International
Author: Shaohui Jia, Shufang Zhang, Hong Yuan, Ning Chen.
2014 Dec 18. 15(12):23705-24
International Journal of Molecular Sciences
Author: Junichi Inaba, Elizabeth J. McConnell, Keith R. Davis.
2014 Dec 5. 111:165-83. Epub 2014 Apr 13
Journal of Proteomics
Author: Margarita Ortiz-Martinez, Robert Winkler, Silverio García-Lara.
2014 Dec. 15(7-8):622-6. Epub 2014 Sep 23
Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.
Author: ALSUntangled Group
2014 Oct 18. 1371C:117-124. [Epub ahead of print]
Journal of Chromatography A
Author: Miguel Guijarro-Díez, Maria Concepcion García, Antonio Luis Crego, Maria Luisa Marina.
2014 Sep 22. 32(42):5411-9. Epub 2014 Aug 12
Vaccine
Author: Chun-Yu Tung CY, David E. Lewis, Ling Han, Moraya Jaja, Shuyu Yao, Fang Li, Michael J. Robertson, Baohua Zhou, Jie Sun, Hua-Chen Chang
2014 Sep. 174(2):612-22. Epub 2014 Aug 2
Applied Biochemistry & Biotechnology
Author: Sarra Setrerrahmane, Yi Zhang, Guangzhi Dai, Jing Lv, Shuhua Tan.
2014 May 15. 151:520-5. Epub 2013 Nov 27
Food Chemistry
Author: Giovanni Dinelli, Valeria Bregola, Sara Bosi, Jessica Fiori, Roberto Gotti, Emanuela Simonetti, Caterina Trozzi, Emanuela Leoncini, Cecilia Prata, Luca Massaccesi, Marco Malaguti, Robert Quinn, Silvana Hrelia.
2014 May 1. 150:174. Epub 2013 Nov 1. No abstract available
Food Chemistry.
Author: Shailendra Kapoor
2014 May. 239(5):519-28. Epub 2014 Mar 13. Review.
Experimental Biology and Medicine (Maywood)
Author: Jones G, Srivastava A
2014 Mar. 79(3):R273-83. Epub 2014 Feb 18
Journal of Food Science
Author: Lidia López-Barrios, Janet A. Gutiérrez-Uribe, Sergio O. Serna-Saldívar.
2014 Mar. 65:155-61. Epub 2013 Dec 21
Food and Chemical Toxicology
Author: García-Nebot MJ, Recio I, Hernández-Ledesma B.
2014 Mar. 63(3):283-95. Epub 2013 Dec 22
Cancer Immunology, Immunotherapy
Author: Hua-Chen Chang, David Lewis, Chun-Yu Tung, Ling Han, Sarah M.P. Henriquez, Larry Voiles, Ivan P. Lupov, David Pelloso, Anthony L. Sinn, Karen E. Pollok, Ben O. de Lumen, Fang Li, Janice S. Blum, Shivani Srivastava, Michael J. Robertson.
2014. 60(1):84-9. Review
Postepy Biochemii
Author: Wołosik K, Markowska A, Kuźmicz I.
2014. 18(14):2070-5
European Review for Medical & Pharmacological Sciences
Author: J. Liu, S.-h. Jia, M. Kirberger, N. Chen
2014
BioMed Research International
Author: Subhadeep Chakrabarti, Forough Jahandideh, Jianping Wu.
2013 Dec 6. 122(21):1042
Blood
Author: Chun-Yu Tung, Sharifah Kyazike, David Lewis, Ling Han, Alexander Kolb, David Pelloso, Anthony Sinn, Karen E. Pollok, Shivani Srivastava, Michael J. Robertson, Hua-Chen Chang.
2013 Dec. 37(6):1014-9. Epub 2013 Oct 21
Cancer Epidemiology
Author: Elena M. Glinka.
2013 Nov 1. 256:5-9. Epub 2013 Aug 8
Behavioral Brain Research
Author: Zane Dzirkale, Juris Rumaks, Simons Svirskis, Olga Mazina, Anni Allikalt, Ago Rinken, Kaspars Jekabsons, Ruta Muceniece, Vija Klusa.
2013 Sep 5. 8(9):e72115. eCollection 2013
PLoS One
Author: Anthony Cam , Mayandi Sivaguru, Elvira Gonzalez de Mejia.
2013 Jul. 4(6B):34-43
Journal of Cancer Therapy
Author: Vermont P. Dia, Elvira Gonzalez de Mejia.
2013 May 1. 138(1):334-41. Epub 2012 Nov 8
Food Chemistry
Author: Vermont P. Dia, Sarah Frankland-Searby, Francisco Laso del Hierro, Guadalupe Garcia G, Elvira Gonzalez de Mejia.
2013 May. 57(3):267-269
Journal of Cereal Science
Author: Rowan A.C. Mitchell, Alison Lovegrove, Peter R. Shewry.
2013 Apr. 20(4):424-32
Protein & Peptide Letters
Author: Blanca Hernández-Ledesma, Chia-Chien Hsieh, Ben O. de Lumen.
2013 Jan. 8(1):79-90. Epub 2012 Aug 3
Genes & Nutrition
Author: John Mark P. Pabona, Bhuvanesh Dave, Ying Su, Maria Theresa E. Montales, Ben O. de Lumen, Elvira Gonzalez de Mejia, Omar M. Rahal, Rosalia C. M. Simmen.
2013. 60(1):107-10. Epub 2013 Mar 21
Acta Biochimica Polonica
Author: Mariola Galbas, Filip Porzucek, Anna Woźniak, Ryszard Słomski, Marek Selwet.
2012 Oct. 56(10):1569-81. Epub 2012 Sep 4
Molecular Nutrition & Food Research
Author: Anthony Cam, Elvira Gonzalez de Mejia.
2012 Aug 15. 60(32):7886-94. Epub 2012 Jul 31
Journal of Agricultural and Food Chemistry
Author: Vermont P. Dia, Tegan Gomez, Gabriela Vernaza, Mark Berhow, Yoon Kil Chang, Elvira Gonzalez de Mejia.
2012 May. 77(5):C539-45. Epub 2012 Apr 17
Journal of Food Science
Author: Ariel Cavazos, Elsy Morales, Vermont P. Dia, Elvira Gonzalez de Mejia.
2012 Feb 29. 11:28
Microbial Cell Factories
Author: Stuart Kyle, Kier AR James, Michael J. McPherson.
2012. 64(1):111-20. Epub 2011 Nov 18
Nutrition and Cancer
Author: Carlo G. Rizzello, Luana Nionelli, Rossana Coda, Marco Gobbetti.
2012. 7(4):e35409. Epub 2012 Apr 13
PLoS One
Author: Lauren E. Seber, Brian W. Barnett, Elizabeth J. McConnell, Steven D. Hume, Jian Cai, Kati Boles, Keith R. Davis.
2011 Oct. 32(10):1979-88. Epub 2011 Sep 16
Peptides
Author: Vermont P. Dia, Elvira Gonzalez de Mejia.
2011 Jul 13. 59(13):6940-6. Epub 2011 Jun 16
Journal of Agricultural and Food Chemistry
Author: Juliana Maria Leite Nobrega de Moura, Blanca Hernandez-Ledesma, Neiva Maria de Almeida, Chia-Chien Hsieh, Ben O. de Lumen, Lawrence A. Johnson.
2011 Jul. 55(7):989-98. Epub 2011 May 25
Molecular Nutrition & Food Research
Author: Blanca Hernández-Ledesma, Chia-Chien Hsieh, Ben O. de Lumen.
2011 Jun. 66(2):107-13
Plant Foods for Human Nutrition
Author: Chia-Chien Hsieh, Blanca Hernández-Ledesma, Ben O. de Lumen.
2011 May. 63(4):623-636
Nutrition and Cancer
Author: Alfredo F. Galvez , Liping Huang , Mark M. J. Magbanua , Kevin Dawson , Raymond L. Rodriguez
2011 Apr. 55(4):623-34. Epub 2011 Jan 5
Molecular Nutrition & Food Research
Author: Vermont P. Dia, Elvira Gonzalez de Mejia.
2010 Nov-Dec. 75(9):H311-6
Journal of Food Science
Author: Chia-Chien Hsieh, Blanca Hernández-Ledesma, Ben O. de Lumen.
2010 Sep 1. 295(1):44-53. Epub 2010 Mar 4
Cancer Letters
Author: Vermont P. Dia, Elvira Gonzalez de Mejia.
2010 Sep. 29(3):511-28
Cancer and Metastasis Reviews
Author: Elvira Gonzalez de Mejia, Vermont P. Dia.
2010 Sep. 88(1):177-86. Epub 2010 Jul 13
Applied Microbiology and Biotechnology
Author: Chin-Feng Liu, Tzu-Ming Pan.
2010 Sep. 31(9):1635-42. Epub 2010 Jun 25
Peptides
Author: Enrique Maldonado-Cervantes, Hyung Jin Jeong, Fabiola León-Galván, Alberto Barrera-Pacheco, De Antonio de León-Rodríguez, Elvira González de Mejia, Ben O. de Lumen, Ana P. Barba de la Rosa.
2010 Jul 30. 186(2):127-34. Epub 2010 May 21
Chemico-Biological Interactions
Author: Chia-Chien Hsieh, Blanca Hernández-Ledesma, Ben O. de Lumen.
2010 Jul 1. 293(1):58-64. Epub 2010 Jan 18
Cancer Letters
Author: Jin Boo Jeong, Ben O. De Lumen, Hyung Jin Jeong.
2010 Mar. 54(3):406-14
Molecular Nutrition & Food Research
Author: Elvira Gonzalez de Mejia, W. Wang, Vermont P. Dia.
2010 Jan 26. 5(1):e8890
PLoS One
Author: Chia-Chen Hsieh, Blanca Hernández-Ledesma, Hyung Jin Jeong, Jae Ho Park, Ben O. de Lumen.
2010. 62(8):1113-9
Nutrition and Cancer
Author: Hyung Jin Jeong, Jin Boo Jeong, Chia-Chien Hsieh, Blanca Hernández-Ledesma, Ben O. de Lumen.
2009 Dec 18. 390(3):803-8. Epub 2009 Oct 15
Biochemical and Biophysical Research Communications
Author: Blanca Hernández-Ledesma, Chia-Chien Hsieh, Ben O. de Lumen.
2009 Dec. 30(12):2388-98. Epub 2009 Aug 12
Peptides
Author: Elvira Gonzalez de Mejia, Vermont P. Dia.
2009 Jul 15. 115(2):574-580
Blanca Hernández-Ledesma, Chia-Chien Hsieh, Ben O. de Lumen.
Author: Food Chemistry
2009 May 1. 114(1):108–115
Food Chemistry
Author: Vermont P. Dia , W. Wang, V.L. Oh, Ben O. de Lumen, Elvira Gonzalez de Mejia
2009 Feb 25. 57(4):1260-6
Vermont P. Dia, Sofia Torres, Ben O. De Lumen, John W. Erdman, Jr., Elvira Gonzalez De Mejia.
Author: Journal of Agricultural and Food Chemistry
2009 Feb. 30(2):426-30. Epub 2008 Nov 13
Peptides
Author: Blanca Hernández-Ledesma, Chia-Chien Hsieh, Ben O. de Lumen.
2009. 61(5):680-6
Nutrition and Cancer
Author: Hyung Jin Jeong, Jeong Rak Lee, Jin Boo Jeong, Jae Ho Park, Young-keun Cheong, Ben O. de Lumen.
2008 Dec 24. 56(24):11707-17
Journal of Agricultural and Food Chemistry
Author: Vermont P. Dia, Mark A. Berhow, Elvira Gonzalez De Mejia.
2008 Jul-Aug. 91(4):936-46
Journal of the Association of Official Analytical Chemists International
Author: Wenyi Wang, Vermont P. Dia, Miguel Vasconez, Elvira Gonzalez de Mejia, Randall L. Nelson.
2008 Jul-Aug. 91(4):932-5
Journal of the Association of Official Analytical Chemists International
Author: Ben O. de Lumen.
2008 Jun 11. 56(11):4012-20. Epub 2008 May 13
Journal of Agricultural and Food Chemistry
Author: Wenyi Wang, Neal A. Bringe, Mark A. Berhow, Elvira Gonzalez de Mejia.
2008 Mar 25. 2:75-80
Perspectives in Medicinal Chemistry
Author: Blanca Hernández-Ledesma, Ben O. de Lumen.
2008 Feb 27. 56(4):1233-40. Epub 2008 Jan 23
Journal of Agricultural & Food Chemistry
Author: C. Silva-Sánchez, A.P. Barba de la Rosa, M.F. León-Galván, Ben O. de Lumen, A. de León-Rodríguez, Elvira Gonzalez de Mejía.
2007 Dec 26. 55(26):10707-13. Epub 2007 Nov 27
Journal of Agricultural & Food Chemistry
Author: Jin Boo Jeong, Hyung Jin Jeong, Jae Ho Park, Sun Hee Lee, Jeong Rak Lee, Hee Kyeong Lee, Gyu Young Chung, Jeong Doo Cho, Ben O. de Lumen.
2007 Dec 26. 55(26):10703-6. Epub 2007 Nov 27
Journal of Agricultural & Food Chemistry
Author: Jae Ho Park, Hyung Jin Jeong, Ben O. de Lumen.
2007 Sep 18. 255(1):42-8. Epub 2007 May 3
Cancer Letters
Author: Hyung Jin Jeong, Jin Boo Jeong, Dae Seop Kim, Jae Ho Park, Jung Bok Lee, Dae-Hyuk Kweon DH, Gyu Young Chung, Eul Won Seo, Ben O. de Lumen.
2007 Feb 7. 55(3):632-7
Journal of Agricultural & Food Chemistry
Author: Hyung Jin Jeong, Jin Boo Jeong, Dae Seop Kim, Ben O. de Lumen.
2005 Oct 5. 53(20):7686-90
Journal of Agricultural & Food Chemistry
Author: Jae Ho Park, Hyung Jin Jeong, Ben O. de Lumen.
2005 Jan. 63(1):16-21. Review
Nutrition Reviews
Author: Ben O. de Lumen.
2004 Sep 22. 52(19):5882-7
Journal of Agricultural & Food Chemistry
Author: Elvira Gonzalez de Mejia, Miguel Vásconez, Ben O. de Lumen, Randall Nelson.
2004 Sep. 123(3):530-6
Journal of Investigative Dermatology
Author: Elaine A. Hsieh, Christine M. Chai, Ben O. de Lumen, Richard A. Neese, Marc K. Hellerstein.
2003 Dec 31. 51(27):7901-6
ournal of Agricultural & Food Chemistry
Author: Hyung Jin Jeong, Jae Ho Park, Yi Lam, Ben O. de Lumen.
2003 Jul. 61(7):239-46. Review. Erratum in: Nutr Rev. 2003 Aug;61(8):293
Nutrition Reviews
Author: Elvira Gonzalez de Mejia, Traliece Bradford, Claire Hasler.
2002 Oct 9. 50(21):5903-8
ournal of Agricultural & Food Chemistry
Author: Hyung Jin Jeong, Yi Lam, Ben O. de Lumen.
2002 Jun. 45(2):96-101
Journal of Plant Biology
Author: Jae Ho Park, Soon Young Kim, Ben O. de Lumen, Kon Joo Lee, Hyung Jin Jeong
2001 Oct 15. 61(20):7473-8
Cancer Research
Author: Alfredo F. Galvez, Na Chen, Janet Macasieb, Ben O. de Lumen.
1999 May. 17(5):495-500
Nature Biotechnology
Author: Alfredo F. Galvez, Ben O. de Lumen.
1987 Aug 05. 262(22):10502-5
The Journal of Biological Chemistry
Author: Odani S, Koide T, Ono T